Congenital Malformations in the Offspring when Drugs for Functional Gastrointestinal Disease were used during Early Pregnancy

In a review of gastrointestinal medications in pregnancy [1] it was pointed out that no large epidemiological study had been published on pregnant women with irritable bowel syndrome and that other forms of functional gastrointestinal disorders during pregnany are also rather little studied. Some drugs used at such conditions have been investigated for a possible effect on the unborn child like drugs used for gastric ulcers or gastro-esophageal reflux diagnosis (GERD) [2-5] and loperamide [6].